The Monitoring and Evaluation (M&E) Framework for the IPC/I package provides adaptable, actionable guidance to review, monitor and measure the implementation, use, learning, and impact of the IPC/I Initiative and its components. The framework highlights how the training and use of the IPC/I package is expected to translate into knowledge and skills of FLWs and their supervisors, and how those knowledge and skills will then lead to improvements in IPC around immunization at the workplace. The M&E Framework outlines recommended steps towards developing monitoring and evaluation for the IPC/I initiative. Additionally, the document includes suggested indicators that can be used to determine the relevance, usage, and effectiveness of the IPC/I package, as well as possible data sources for those indicators.